Mature 777

Adamski, a police officer in Berlin who investigates organized crime, first started going to a nudist camp at a lake outside Berlin after he met his wife, whose family owned a cabin there. One weekend, when he had just about gotten used to stripping in front of his in-laws, he bumped into the highest-ranking colonel in his precinct — who promptly challenged him to a game of table tennis. Adamski said as he prepared to join a triathlon where the swimming and running portions of the race were naked. Germans love to get naked.

Indeed, mucous cell metaplasia is considered the critical preneoplastic lesion for gastric cancer. Previous investigations have shown that infection of mice with Helicobacter felis or induction of acute parietal cell loss with the drug DMP leads to the emergence of a type of metaplasia designated spasmolytic polypeptide-expressing metaplasia SPEM. We have hypothesized that SPEM arises from proliferating cells in gland bases, either from a cryptic progenitor cell or by transdifferentiation of mature chief cells. Methods: Taking advantage of the chief cell-restricted expression of Mist1-Cre-ER T2 , we used lineage mapping to examine whether SPEM lineages were derived from chief cells in 3 independent models of induction by DMP treatment, L treatment, or H felis infection. Results: Treatment of mice with L for 3 days led to rapid parietal cell loss, induction of a prominent inflammatory infiltrate, and emergence of SPEM.

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